Beilstein J. Org. Chem.2014,10, 1037–1046, doi:10.3762/bjoc.10.104
in many nanotechnological approaches. Inspired by naturally existing self-assembled DNA architectures, branchedDNA has been developed that allows self-assembly to predesigned architectures with dimensions on the nanometer scale. DNA is an attractive material for generation of nanostructures due to a
hydrogels.
Keywords: AFM; branchedDNA; DNA; DNA polymerase; nanotechnology; nucleic acids; PCR; self-assembly; Introduction
DNA has found applications in the field of nanotechnology due to its inherent properties. The simplicity and predictability of DNA secondary structure are of outstanding potential
for the design of self-assembled architectures [1][2][3]. Inspired by naturally existing self-assembled DNA architectures known as Holliday junctions, Seeman envisioned the approach to organize DNA with branchedDNA (bDNA) and thereby initiated the field of structural DNA nanotechnology [4]. Since
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Graphical Abstract
Scheme 1:
Reagents and conditions: (a) PdCl2(PPh3)2, DMF, CuI, NEt3, 55 °C, microwave, 82%; (b) PdCl2(PPh3)2,...